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Observe Intently (two)pentobarbital will lessen the level or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Robust CYP3A4 inducers might minimize suvorexant efficacy; if improved suvorexant dose demanded, usually do not exceed 20 mg/daypentobarbital will lower the extent or impact of elbas